Supplemental Figure 1. Notch4 mRNA expression correlates with Notch ligands and downstream effectors; Supplemental Figure 2. A schematic outline of experimental procedures; Supplemental Figure 3. A single Notch+ cell has the capacity to generate tumors that represents the initial heterogeneity; Supplemental Figure 4. Evaluation of tumor growth following the treatment of animals with GSI, Docetaxel or combination treatments.