Semi-synthesis of a protease-activatable collagen targeting probe
- 20 June 2011
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 47 (28), 7998-8000
- https://doi.org/10.1039/c1cc11964h
Abstract
A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity.Keywords
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