Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells
- 3 February 2010
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 2 (17), 17ra9
- https://doi.org/10.1126/scitranslmed.3000349
Abstract
CD32 and CD25, molecules specifically found in human leukemia stem cells, are promising targets for therapy.Keywords
This publication has 52 references indexed in Scilit:
- Interleukin-2 receptor alpha-chain (CD25) expression on leukaemic blasts is predictive for outcome and level of residual disease in AMLEuropean Journal of Cancer, 2009
- Contrasting genetic association of IL2RAwith SLE and ANCA – associated vasculitisBMC Medical Genetics, 2009
- Dysregulated gene expression networks in human acute myelogenous leukemia stem cellsProceedings of the National Academy of Sciences of the United States of America, 2009
- An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemiaBlood, 2008
- High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) studyBlood, 2008
- Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignanciesBlood, 2008
- Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetesNature Genetics, 2007
- The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer CellsThe New England Journal of Medicine, 2007
- Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem CellsCancer Research, 2006
- Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experimentsFEBS Letters, 2004