Ferrous versus Ferric Oral Iron Formulations for the Treatment of Iron Deficiency: A Clinical Overview
Open Access
- 1 January 2012
- journal article
- review article
- Published by Hindawi Limited in The Scientific World Journal
- Vol. 2012, 1-5
- https://doi.org/10.1100/2012/846824
Abstract
Iron deficiency anaemia represents a major public health problem, particularly in infants, young children, pregnant women, and females with heavy menses. Oral iron supplementation is a cheap, safe, and effective means of increasing haemoglobin levels and restoring iron stores to prevent and correct iron deficiency. Many preparations are available, varying widely in dosage, formulation (quick or prolonged release), and chemical state (ferrous or ferric form). The debate over the advantages of ferrous versus ferric formulations is ongoing. In this literature review, the tolerability and efficacy of ferrous versus ferric iron formulations are evaluated. We focused on studies comparing ferrous sulphate preparations with ferric iron polymaltose complex preparations, the two predominant forms of iron used. Current data show that slow-release ferrous sulphate preparations remain the established and standard treatment of iron deficiency, irrespective of the indication, given their good bioavailability, efficacy, and acceptable tolerability demonstrated in several large clinical studies.Keywords
This publication has 36 references indexed in Scilit:
- Hepcidin: from discovery to differential diagnosisHaematologica, 2008
- Iron homeostasis and inherited iron overload disorders: an overviewHematology/Oncology Clinics of North America, 2004
- PHYSIOLOGY AND MOLECULAR BIOLOGY OF DIETARY IRON ABSORPTIONAnnual Review of Nutrition, 2003
- Changes in markers of anemia and iron metabolism and how they are influenced by antianemics in postpartum periodActa Obstetricia et Gynecologica Scandinavica, 2001
- A Primary Prevention Trial Using Nutritional Doses of Antioxidant Vitamins and Minerals in Cardiovascular Diseases and Cancers in a General Population: The SU.VI.MAX Study—Design, Methods, and Participant CharacteristicsControlled Clinical Trials, 1998
- Comparative bioavailability of ferric polymaltose and ferrous sulphate in iron-deficient blood donorsJournal of Clinical Apheresis, 1993
- Assessment of iron availability using stable54FeEuropean Journal of Clinical Investigation, 1991
- Side‐Effect Studies on a New Sustained Release Iron PreparationScandinavian Journal of Haematology, 1971
- Iron Preparations for AnaemiaBMJ, 1960
- IRON-DEFICIENCY ANÆMIA IN PREGNANCYThe Lancet, 1955