Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation
- 25 August 2010
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 467 (7316), 719-723
- https://doi.org/10.1038/nature09390
Abstract
The chromosomal passenger complex (CPC) coordinates several processes during cell division, including chromosome bi-orientation and cytokinesis, and its proper localization is crucial. These authors provide a mechanism for its localization to the inner centromere. Cdk1-cyclin-B-dependent phosphorylation of the CPC promotes binding to shugoshin, which the authors define as a conserved centromeric adaptor of the CPC. This mechanism is conserved between fission yeast and human cells and highlights a crucial role of Cdk1-cyclin B in chromosome bi-orientation.Keywords
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