Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
- 12 January 2007
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5809), 187
- https://doi.org/10.1126/science.1129402
Abstract
Herbert et al . (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.Keywords
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