FACTORS CONTROLLING SERUM γ-GLOBULIN CONCENTRATION
Open Access
- 1 November 1963
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 118 (5), 845-868
- https://doi.org/10.1084/jem.118.5.845
Abstract
Both synthetic and catabolic processes determine the serum gamma-globulin level. The rate of gamma-globulin synthesis appears to be the primary factor determining the amount of serum gamma-globulin. Increase of gamma-globulin synthesis (as may occur following immunization or development of plasma cell tumor) elevates the serum gamma-globulin level. This, in turn, accelerates the fractional rate of gamma-globulin catabolism. The change in catabolic rate reduces the dimensions of the serum change from which would occur if synthesis alone determined the serum gamma-globulin level. The present studies indicate the existence of a homeostatic mechanism controlling the rate of gamma-globulin catabolism. The mechanisms of gamma-globulin catabolism are specific and selective. Marked serum increase of other immunoglobulin components (B2A-globulins and gamma1-macroglobulins) do not accelerate gamma-globulin catabolism. Similarly, serum albumin increases do not influence gamma-globulin catabolism.Keywords
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