Estimation of the Relative Sensitivity of the Comparative Tuberculin Skin Test in Tuberculous Cattle Herds Subjected to Depopulation
Open Access
- 21 August 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (8), e43217
- https://doi.org/10.1371/journal.pone.0043217
Abstract
Bovine tuberculosis (bTB) is one of the most serious economic animal health problems affecting the cattle industry in Great Britain (GB), with incidence in cattle herds increasing since the mid-1980s. The single intradermal comparative cervical tuberculin (SICCT) test is the primary screening test in the bTB surveillance and control programme in GB and Ireland. The sensitivity (ability to detect infected cattle) of this test is central to the efficacy of the current testing regime, but most previous studies that have estimated test sensitivity (relative to the number of slaughtered cattle with visible lesions [VL] and/or positive culture results) lacked post-mortem data for SICCT test-negative cattle. The slaughter of entire herds (“whole herd slaughters” or “depopulations”) that are infected by bTB are occasionally conducted in GB as a last-resort control measure to resolve intractable bTB herd breakdowns. These provide additional post-mortem data for SICCT test-negative cattle, allowing a rare opportunity to calculate the animal-level sensitivity of the test relative to the total number of SICCT test-positive and negative VL animals identified post-mortem (rSe). In this study, data were analysed from 16 whole herd slaughters (748 SICCT test-positive and 1031 SICCT test-negative cattle) conducted in GB between 1988 and 2010, using a Bayesian hierarchical model. The overall rSe estimate of the SICCT test at the severe interpretation was 85% (95% credible interval [CI]: 78–91%), and at standard interpretation was 81% (95% CI: 70–89%). These estimates are more robust than those previously reported in GB due to inclusion of post-mortem data from SICCT test-negative cattle.Keywords
This publication has 16 references indexed in Scilit:
- Advances in ante-mortem diagnosis of tuberculosis in cattleNew Zealand Veterinary Journal, 2009
- Ante mortem diagnosis of tuberculosis in cattle: A review of the tuberculin tests, γ-interferon assay and other ancillary diagnostic techniquesResearch in Veterinary Science, 2006
- Surveillance and risk management during the latter stages of eradication: Experiences from AustraliaVeterinary Microbiology, 2006
- Towards eradication of bovine tuberculosis in the European UnionVeterinary Microbiology, 2006
- Performance of the single intradermal comparative tuberculin test in identifying cattle with tuberculous lesions in Irish herdsVeterinary Record, 1997
- Effect of a recent injection of purified protein derivative on diagnostic tests for tuberculosis in cattle infected with Mycobacterium bovisResearch in Veterinary Science, 1995
- The tuberculin testVeterinary Microbiology, 1994
- Field trials to determine a suitable injection dose of bovine PPD tuberculin for the diagnosis of bovine tuberculosis in naturally infected cattle.1986
- Comparison of the specificty of human and bovine tuberculin PPD for testing cattle. 1--Republic of IrelandVeterinary Record, 1975
- Studies on tuberculin sensitivity in the bovine; introduction.1946