Sarcoidosis of the anterior visual pathway: successes and failures.
- 1 December 1988
- journal article
- case report
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 51 (12), 1473-1480
- https://doi.org/10.1136/jnnp.51.12.1473
Abstract
Four patients with progressive visual deterioration were found to have sarcoidosis involving the anterior visual pathway. They all developed chiasmal dysfunction and bilateral optic neuropathy, which responded to megadose corticosteroid therapy. When an attempt was made to withdraw the corticosteroids, the patients experienced a recrudescence of visual dysfunction and were subsequently unable to tolerate the corticosteroid dose levels necessary to maximise their visual potential. Each patient was treated with high-voltage radiation therapy, totalling up to 4500 rads. The beneficial response obtained was temporary, and immunosuppressive therapy with azathioprine or chlorambucil was instituted, preventing further deterioration.Keywords
This publication has 16 references indexed in Scilit:
- Optic neuropathy in sarcoidosis.Journal of Neurology, Neurosurgery & Psychiatry, 1986
- Treatment of central nervous system sarcoidosis with radiotherapyAnnals of Neurology, 1985
- Neuro‐ophthalmologic signs in the angiitic form of neurosarcoidosisNeurology, 1983
- Chiasmal Syndrome in SarcoidosisAmerican Journal of Ophthalmology, 1983
- Drug therapy reviews: Treatment of sarcoidosisAmerican Journal of Health-System Pharmacy, 1979
- Sarcoid-like disorder of the intracranial optic nerve: Clinicopathological report of two casesJournal of Neurology, Neurosurgery & Psychiatry, 1977
- [Therapy of Boeck's sarcoidosis using immunosuppressive substances. Experience with azathioprine (Imurel)].1969
- Spontaneous Remission or Response to Methotrexate in SarcoidosisAnnals of Internal Medicine, 1968
- The treatment of sarcoidosis with chloroquineAmerican Journal Of Medicine, 1961
- Noninfectious granulomatous angiitis with a predilection for the nervous systemNeurology, 1959