Natural Products as Platforms To Overcome Antibiotic Resistance
Top Cited Papers
- 27 September 2017
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Reviews
- Vol. 117 (19), 12415-12474
- https://doi.org/10.1021/acs.chemrev.7b00283
Abstract
Natural products have served as powerful therapeutics against pathogenic bacteria since the golden age of antibiotics of the mid-20th century. However, the increasing frequency of antibiotic-resistant infections clearly demonstrates that new antibiotics are critical for modern medicine. Because combinatorial approaches have not yielded effective drugs, we propose that the development of new antibiotics around proven natural scaffolds is the best short-term solution to the rising crisis of antibiotic resistance. We analyze herein synthetic approaches aiming to reengineer natural products into potent antibiotics. Furthermore, we discuss approaches in modulating quorum sensing and biofilm formation as a nonlethal method, as well as narrow-spectrum pathogen-specific antibiotics, which are of interest given new insights into the implications of disrupting the microbiome.Funding Information
- Division of Chemistry (CHE-1454116)
- Temple University
- National Institute of General Medical Sciences (R35 GM119426)
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