Supplementary Figures S1-S5 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment

Abstract

Effects of chemokines and TGF-B on T-cell adhesion to recombinant molecules and specific tumor cells (S1); Influence of TGF-B and chemokines on integrin expression and T-cell motility (S2); Tumor slice staining, influence of anti-CD103 on calcium response and ILK phosphorylation and effect of TGF-B and chemical inhibitors on ILK expression and T-cell adhesion (S3); Influence of siRNA-E-cadherin, shRNA-ILK and rTGF-B on CD103, phospho-ILK and TGFBRI polarization (S4); Effects of TGF-B and chemical inhibitors on granzyme B polarization or redirected target cell lysis (S5).