Establishment of Four Functional, Clonal Strains of Animal Cells in Culture
- 2 December 1966
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 154 (3753), 1186-1189
- https://doi.org/10.1126/science.154.3753.1186
Abstract
The single-cell plating technique was used to develop four clonal cell lines that perform organ-specific functions after being serially cultured for prolonged periods. These strains include steroid-secreting Leydig cells, melanomacells that form pigment, and two strains from a hormone-secreting rat pituitary tumor. One of the cell lines from the pituitary tumor secretes growt hormone, while another line derived from the same tumor secretes a substance similar to adrenocorticotropic hormone.Keywords
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