Histopathology and prognosis of Wilms tumorResults from the first national wilms' tumor study
- 1 May 1978
- Vol. 41 (5), 1937-1948
- https://doi.org/10.1002/1097-0142(197805)41:5<1937::aid-cncr2820410538>3.0.co;2-u
Abstract
Detailed histological analysis of 427 cases entered on the first national Wilms' tumor study revealed that lesions with foci of marked cytological atypism (anaplasia), and those composed predominantly of sarcomatous stroma, were associated with unfavorable outcome. Twenty-five patients had anaplasia, and 24 had sarcomatous lesions of which a total of 28 (57.1%) died of tumor. Three hundred and seventy-eight patients had tumors which showed neither of these features, and only 26 (6.9%) died of tumor. Seven of ten deaths due to tumor in patients diagnosed before two years of age were associated with sarcomatous lesions. three sarcomatous patterns were recognized, of which one, designated “clear cell” sarcoma, had a predilection for bony metastases. Using criteria defined and illustrated in this paper it is possible to identify in advance those patients likely to do poorly using current therapeutic approaches.Keywords
This publication has 12 references indexed in Scilit:
- Perspectives on the statistician's role in cooperative clinical researchCancer, 1978
- The treatment of Wilms' tumor. Results of the national Wilms' tumor studyCancer, 1976
- Mitosis counting—IIHuman Pathology, 1976
- Wilms' tumor: Natural history and prognostic factors.A retrospective study of 248 cases treated at the institut Gustave-Roussy 1952–1967Cancer, 1976
- Wilms' tumor—histologic variation and prognosisCancer, 1975
- Mesenchymal renal neoplasms of infancy revisitedJournal of Pediatric Surgery, 1974
- Structure and size versus prognosis in nephroblastomaCancer, 1973
- Wilms Tumor: A Clinical Pathological CorrelationJournal of Urology, 1973
- Wilms TumorsJournal of Urology, 1961
- Ueber die Anaplasie der Geschwulstzellen und die asymmetrische MitoseVirchows Archiv, 1892