Human Autologous Serum for the Treatment of Full-thickness Macular Holes
Open Access
- 1 July 1995
- journal article
- Published by Elsevier BV in Ophthalmology
- Vol. 102 (7), 1071-1076
- https://doi.org/10.1016/s0161-6420(95)30909-8
Abstract
Recent studies have shown the usefulness of pars plana vitrectomy with/or without the use of transforming growth factor-beta in treating macular holes. The purpose of the present study is to test the efficacy of autologous serum in conjunction with current surgical techniques in the repair of stage 3 or 4 macular holes. A total of 11 eyes in nine patients with stage 3 or 4 full-thickness macular holes were treated. The patients ranged in age from 53 to 80 years (mean, 68 years). These patients were followed for 4 to 11 months (mean, 8.4 months). Preoperative best-corrected visual acuity ranged from 2/200 to 20/80 (mean, 20/200). A standardized pars plana vitrectomy was performed with removal of the posterior hyaloid and/or removal of epiretinal membranes, fluid-gas exchange. Autologous serum (0.1 ml) was instilled over the macular hole followed by perfluorocarbon gas tamponade and head positioning for 2 weeks. All 11 (100%) of the eyes in 9 patients had resolution of the surrounding subretinal fluid and flattening of the macular hole. All of the eyes showed an improvement of at least two lines or more (mean, 4.7 lines) in visual acuity. Three eyes (27%) had visual acuities of 20/40 or better, and seven (64%) had visual acuities of 20/60 or better. No exuberant fibrosis proliferation was noted in any eye. The results of this preliminary study indicate the possible benefit of autologous serum when used in conjunction with current surgical techniques in treating stage 3 or 4 macular holes.Keywords
This publication has 26 references indexed in Scilit:
- Induction of retinal regeneration in vivo by growth factorsDevelopmental Biology, 1991
- INTRAVITREAL BIOCOMPATIBILITY OF MUSSEL ADHESIVE PROTEINRetina, 1990
- Basic fibroblast growth factor induces retinal regeneration in vivoDevelopmental Biology, 1989
- Serum Is Chemotactic for Retinal-Derived Glial CellsAmerican Journal of Ophthalmology, 1988
- Focal Adhesions and Cell-Matrix InteractionsCollagen and Related Research, 1988
- RETINAL TOXICITY OF CYANOACRYLATE TISSUE ADHESIVE IN THE RABBITRetina, 1988
- A BIOLOGIC TISSUE ADHESIVE FOR VITREORETINAL SURGERYRetina, 1988
- Apparent Disappearance of a Macular Hole Associated With Development of an Epiretinal MembraneAmerican Journal of Ophthalmology, 1986
- Sealing of retinal breaks with metal tacksActa Ophthalmologica, 1986
- Serum Contains Chemoattractants for Human Retinal Pigment Epithelial CellsAmerican Journal of Ophthalmology, 1984