A biobehavioral model of cancer stress and disease course.
- 1 January 1994
- journal article
- review article
- Published by American Psychological Association (APA) in American Psychologist
- Vol. 49 (5), 389-404
- https://doi.org/10.1037//0003-066x.49.5.389
Abstract
Approximately 1 million Americans are diagnosed with cancer each year and must cope with the disease and treatments. Many studies have documented the deteriorations in quality of life that occur. These data suggest that the adjustment process is burdensome and lengthy. There is ample evidence showing that adults experiencing other long-term stressors experience not only high rates of adjustment difficulties (e.g., syndromal depression) but important biologic effects, such as persistent downregulation of elements of the immune system, and adverse health outcomes, such as higher rates of respiratory tract infections. Thus, deteriorations in quality of life with cancer are underscored if they have implications for biological processes, such as the immune system, relating to disease progression and spread. Considering these and other data, a biobehavioral model of adjustment to the stresses of cancer is offered, and mechanisms by which psychological and behavioral responses may influence biological processes and, perhaps, health outcomes are proposed. Finally, strategies for testing the model via experiments testing psychological interventions are offered.Keywords
This publication has 100 references indexed in Scilit:
- Patient noncompliance with self-administered chemotherapyCancer, 1990
- Disclosure of traumas and immune function: Health implications for psychotherapy.Journal of Consulting and Clinical Psychology, 1988
- Psychological influences on immunity: Implications for AIDS.American Psychologist, 1988
- Infection in cancer patients: A continuing associationAmerican Journal Of Medicine, 1986
- Group coping skills instruction and supportive group therapy for cancer patients: A comparison of strategies.Journal of Consulting and Clinical Psychology, 1986
- Effects of Chemotherapeutic Agents on the Immune Response. IICancer Investigation, 1985
- Effects of Chemotherapeutic Agents on the Immune Response. ICancer Investigation, 1984
- Dose-Response Effect of Adjuvant Chemotherapy in Breast CancerNew England Journal of Medicine, 1981
- Influence of Adherence to Treatment and Response of Cholesterol on Mortality in the Coronary Drug ProjectNew England Journal of Medicine, 1980
- Effect of therapeutic irradiation on the immune responsesAmerican Journal of Roentgenology, 1976