Perspective: How Might Emmetropization and Genetic Factors Produce Myopia in Normal Eyes?
- 1 March 2011
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Optometry and Vision Science
- Vol. 88 (3), E365-E372
- https://doi.org/10.1097/opx.0b013e31820b053d
Abstract
Substantial evidence has emerged over the past decades for a role of genetics in the development of human refractive error. There is also an emmetropization mechanism that uses visual signals to match the axial length to the focal plane. There has been little discussion of how these two important factors might interact. We explore here ways in which genetic factors driving axial growth may interact with the emmetropization mechanism, mostly to produce emmetropic eyes but often to produce myopia. An important factor may be a normal, yet reduced ability of juvenile eyes to use myopia to restrain genetically driven axial elongation. Reduced ability to respond to myopia by slowing axial elongation may contribute to the development of myopia in cases where genetics alone would make the axial length longer than the focal plane.This publication has 65 references indexed in Scilit:
- Binocular lens treatment in tree shrews: Effect of age and comparison of plus lens wear with recovery from minus lens-induced myopiaExperimental Eye Research, 2010
- Hundreds of variants clustered in genomic loci and biological pathways affect human heightNature, 2010
- Nature of the refractive errors in rhesus monkeys (Macaca mulatta) with experimentally induced ametropiasVision Research, 2010
- The effect of age on compensation for a negative lens and recovery from lens-induced myopia in tree shrews (Tupaia glis belangeri)Vision Research, 2010
- Accommodation and induced myopia in marmosetsVision Research, 2007
- Temporal Constraints on Experimental Emmetropization in Infant MonkeysInvestigative Ophthalmology & Visual Science, 2007
- Darkness Causes Myopia in Visually Experienced Tree ShrewsInvestigative Ophthalmology & Visual Science, 2006
- Refractive Errors in Twin StudiesTwin Research and Human Genetics, 2006
- Selective Regulation of MMP and TIMP mRNA Levels in Tree Shrew Sclera during Minus Lens Compensation and RecoveryInvestigative Ophthalmology & Visual Science, 2005
- Axial Growth and Changes in Lenticular and Corneal Power during Emmetropization in InfantsInvestigative Ophthalmology & Visual Science, 2005