Correlates of Sleep and Waking in Drosophila melanogaster
Top Cited Papers
- 10 March 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 287 (5459), 1834-1837
- https://doi.org/10.1126/science.287.5459.1834
Abstract
Drosophila exhibits a circadian rest-activity cycle, but it is not known whether fly rest constitutes sleep or is mere inactivity. It is shown here that, like mammalian sleep, rest in Drosophila is characterized by an increased arousal threshold and is homeostatically regulated independently of the circadian clock. As in mammals, rest is abundant in young flies, is reduced in older flies, and is modulated by stimulants and hypnotics. Several molecular markers modulated by sleep and waking in mammals are modulated by rest and activity in Drosophila , including cytochrome oxidase C, the endoplasmic reticulum chaperone protein BiP, and enzymes implicated in the catabolism of monoamines. Flies lacking one such enzyme, arylalkylamine N -acetyltransferase, show increased rest after rest deprivation. These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep.Keywords
This publication has 24 references indexed in Scilit:
- Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythmsThe Journal of Physiology, 1999
- Molecular and Biochemical Characterization of the aaNATl (Dat) Locus in Drosophila melanogaster: Differential Expression of Two Gene ProductsDNA and Cell Biology, 1998
- 24‐h variation of vigilance in the cockroach Blaberus giganteusJournal of Sleep Research, 1992
- Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER.The Journal of cell biology, 1992
- A function for REM sleep: regulation of noradrenergic receptor sensitivityBrain Research Reviews, 1988
- Germ-Line Transformation Involving DNA from theperiodLocus inDrosophila melanogaster: Overlapping Genomic Fragments that Restore Circadian and Ultradian Rhythmicity toper0andper−MutantsJournal of Neurogenetics, 1986
- Animal sleep: A review of sleep duration across phylogenyNeuroscience & Biobehavioral Reviews, 1984
- Neuronal correlates of sleep, wakefulness and arousal in a diurnal insectNature, 1983
- Dorsal raphe neurons: depression of firing during sleep in catsBrain Research, 1976
- Mammalian Sleep, Longevity, and Energy Metabolism; pp. 425–446Brain, Behavior and Evolution, 1974