Donor-Related Candida Keratitis After Descemet Stripping Automated Endothelial Keratoplasty
- 1 August 2009
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Cornea
- Vol. 28 (7), 825-828
- https://doi.org/10.1097/ico.0b013e31819140c4
Abstract
To report 2 cases of donor-to-host transmission of Candida albicans interface keratitis after Descemet stripping automated endothelial keratoplasty (DSAEK). We performed clinical and microbiologic examinations on 2 patients who underwent DSAEK for pseudophakic corneal edema. Two patients underwent uneventful DSAEK surgery using corneal tissue from the same donor. The donor corneoscleral rims were cultured at the time of surgery and both rims subsequently grew C. albicans and Candida glabrata. Approximately 5 weeks after surgery, infiltrates were noted in the DSAEK interface in both of these patients. Despite treatment with antifungal therapy, the Candida keratitis was unable to be controlled medically and required surgical intervention in each case, after which there was no recurrence of infection. Candida interface keratitis can occur after DSAEK. These 2 cases emphasize the importance of donor corneoscleral rim cultures, especially with the increase in lamellar and endothelial keratoplasty, which can make such interface infections more difficult to diagnose and treat. Patients with fungal positive donor corneal rim cultures should be prophylactically treated with antifungal therapy.Keywords
This publication has 21 references indexed in Scilit:
- The Prognostic Role of Donor Corneoscleral Rim Cultures in Corneal TransplantationOphthalmology, 2007
- The Incidence of Fungal Keratitis and Endophthalmitis Following Penetrating KeratoplastyCornea, 2005
- The Prevalence and Risk Factors for Donor Corneal Button Contamination and Its Association With Ocular Infection After TransplantationCornea, 2004
- The value of routine donor corneal rim cultures in penetrating keratoplasty.American Journal of Ophthalmology, 1997
- Bacterial and Fungal Endophthalmitis After Penetrating KeratoplastyAmerican Journal of Ophthalmology, 1993
- Donor Cornea Bacterial ContaminationCornea, 1991
- Contamination of Donor Cornea: Postpenetrating Keratoplasty EndophthalmitisCornea, 1991
- Endophthalmitis From Contaminated Donor Corneas Following Penetrating KeratoplastyAmerican Journal of Ophthalmology, 1991
- Corneal Rim CulturesCornea, 1987
- Endophthalmitis Following Penetrating KeratoplastyOphthalmology, 1983