Hematoma Growth in Oral Anticoagulant Related Intracerebral Hemorrhage
- 1 November 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 39 (11), 2993-2996
- https://doi.org/10.1161/strokeaha.108.520668
Abstract
Background and Purpose— Limited data suggest that intracerebral hemorrhage related to oral anticoagulant therapy (OAT ICH) is associated with more hemorrhage expansion and a worse prognosis than spontaneous ICH (SICH). Methods— We examined patients enrolled in the placebo arm of the CHANT study, a prospective randomized trial of a putative neuroprotectant in patients with ICH. All patients had neuroimaging within 6 hours of symptom onset and at 72 hours. Initial ICH volume and hemorrhage expansion were determined by a central reader. Multivariable logistic regression was used to determine factors associated with ICH expansion and mortality at 90 days. Results— Of 303 patients included, 21 (6.9%) had OAT ICH. Baseline median ICH volume was greater in patients with OAT ICH compared to SICH (30.6 versus 14.4 mL, P =0.03). Hemorrhage expansion (defined as >33% increase in ICH volume) occurred in 56% of patients with OAT ICH compared to 26% of SICH ( P =0.006). Mortality was substantially higher in OAT ICH (62% versus 17%, P Conclusions— These findings confirm that OAT ICH is associated with more hemorrhage expansion and greater mortality than SICH.This publication has 9 references indexed in Scilit:
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