Possible effect of environmental exposure to asbestos on geographical variation in mesothelioma rates
- 1 June 2010
- journal article
- research article
- Published by BMJ in Occupational and Environmental Medicine
- Vol. 67 (6), 417-421
- https://doi.org/10.1136/oem.2009.050336
Abstract
Background In population-based mesothelioma studies in industrialised countries, the incidence of mesothelioma without any identified asbestos exposure (IAE) is usually higher among women, while male incidence is mainly attributed to IAE. Through a comparison of the spatial distribution of male and female rates, and IAE and no IAE incidence, this study investigated whether mesotheliomas without IAE are in fact induced by non-recognised asbestos exposure, mostly from environmental sources. Methods We calculated mesothelioma mortality (SMR) and incidence (SIR) ratios by district in France, pooling 30 and 10 years of data, respectively. Using correlation coefficients, we compared geographical patterns of male and female mesothelioma ratios, and IAE and no IAE mesothelioma ratios. Results The raw numbers of male and female mesothelioma cases were equivalent. Mesothelioma SMR (0.76) and SIR (0.80) geographical correlations between men and women were strongly positive. SIR correlation between occupationally IAE and no IAE cases was also positive (0.69). Correlation between occupationally IAE and no IAE cases was positive among women but not among men. Conclusions Data analyses of mesothelioma mortality and incidence showed that female cases occur in the same geographical areas as male cases. Female mesotheliomas with no IAE occur in the same geographical areas as exposed cases, suggesting asbestos has a major influence on female mesothelioma, likely through environmental exposure.Keywords
This publication has 20 references indexed in Scilit:
- The health impact of nonoccupational exposure to asbestos: what do we know?European Journal of Cancer Prevention, 2009
- Occupational, domestic and environmental mesothelioma risks in the British population: a case–control studyBritish Journal of Cancer, 2009
- Modeling Mesothelioma Risk Associated with Environmental Asbestos ExposureEnvironmental Health Perspectives, 2007
- The French National Mesothelioma Surveillance ProgramOccupational and Environmental Medicine, 2006
- Malignant mesothelioma in Italy, 1997American Journal of Industrial Medicine, 2003
- Increased risk of malignant mesothelioma of the pleura after residential or domestic exposure to asbestos: a case-control study in Casale Monferrato, Italy.Environmental Health Perspectives, 2001
- Malignant mesothelioma from neighborhood exposure to anthophyllite asbestosAmerican Journal of Industrial Medicine, 2001
- The epidemiology of mesothelioma in historical contextEuropean Respiratory Journal, 1996
- Epidemiology of Asbestos-Related DiseasesEnvironmental Health Perspectives, 1980
- MESOTHELIOMA OF PLEURA AND PERITONEUM FOLLOWING EXPOSURE TO ASBESTOS IN THE LONDON AREAOccupational and Environmental Medicine, 1965