Photosensitizers for Photodynamic Therapy
Top Cited Papers
- 8 May 2019
- journal article
- review article
- Published by Wiley in Advanced Healthcare Materials
- Vol. 8 (13), e1900132
- https://doi.org/10.1002/adhm.201900132
Abstract
As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O2). However, further advancements including tumor selectivity and ROS generation efficiency are still required. Substantial efforts are devoted to design and synthesize smart PSs with optimized properties for achieving a desirable therapeutic efficacy. This review summarizes the recent progress in developing intelligent PSs for efficient PDT, ranging from single molecules to delicate nanomaterials. The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted. Moreover, the approaches that combine PDT with other therapeutics (e.g., chemotherapy, photothermal therapy, and radiotherapy) and the targeted delivery in cancer cells or tumor tissue are introduced. The main challenges for the clinical application of PSs are also discussed.Keywords
Funding Information
- National Natural Science Foundation of China (61720106014, 61805287)
- Natural Science Foundation of Hubei Province (2018JJ3632)
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