Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses.
- 1 February 1975
- journal article
- clinical trial
- Published by BMJ in Sexually Transmitted Infections
- Vol. 51 (1), 51-53
- https://doi.org/10.1136/sti.51.1.51
Abstract
Serum concentrations of tinidazole and metronidazole have been measured in healthy female volunteers who received a single dose of 2 g. of each drug in a cross-over study. Bioassays against T. vaginalis showed that metronidazole achieved higher peak concentrations (mean 81 mug./ml.) than did tinidazole (mean 67 mug./ml.), while assays for unchanged drug showed higher peak concentrations of tinidazole )mean 51 mug./ml;) than of metronidazole (mean 40 mug./ml9). This discrepancy is probably due to the presence in the serum of active metabolites of metronidazole. The longer half-life of tinidazole led to significantly higher serum concentrations (by bioassay and chemical assay) of tinidazole than of metronidazole from 6 hrs onwards.This publication has 8 references indexed in Scilit:
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