Signal Transduction and the Control of Gene Expression
- 1 February 2002
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 295 (5556), 813-818
- https://doi.org/10.1126/science.1066355
Abstract
More than 2000 transcription factors are encoded in the human genome. Such proteins have often been classified according to common structural elements. But because transcription factors evolved in the service of biologic function, we propose an alternative grouping of eukaryotic transcription factors on the basis of characteristics that describe their roles within cellular regulatory circuits.This publication has 89 references indexed in Scilit:
- A Glucocorticoid/Retinoic Acid Receptor Chimera That Displays Cytoplasmic/Nuclear Translocation in Response to Retinoic AcidPublished by Elsevier BV ,2001
- Translating the Histone CodeScience, 2001
- Generic Signals and Specific Outcomes: Signaling through Ca2+, Calcineurin, and NF-ATCell, 1999
- TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and FunctionAnnual Review of Immunology, 1997
- Partnership between DPC4 and SMAD proteins in TGF-β signalling pathwaysNature, 1996
- Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombinationCurrent Opinion in Cell Biology, 1995
- Activation of ternary complex factor Elk-1 by stress-activated protein kinasesCurrent Biology, 1995
- Gene regulation by Ets proteinsBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1993
- The origin of pattern and polarity in the Drosophila embryoCell, 1992
- Genetic regulatory mechanisms in the synthesis of proteinsJournal of Molecular Biology, 1961