Aprindine

Abstract

Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or i.v. in the treatment of ventricular arrhythmias of varying etiologies. It may be especially useful in the treatment of the Wolff-Parkinson-White syndrome and in the treatment of atrial arrhythmias. Side effects can be minimized by careful titration of the dose of aprindine. If the frequency of such serious side effects as cholestatic jaundice and agranulocytosis remains low enough, aprindine should be a useful addition to currently available antiarrhythmic drugs.