Clinical correlates of dementia and disability in Huntington's disease
- 1 November 1984
- journal article
- research article
- Published by Informa UK Limited in Journal of Clinical Neuropsychology
- Vol. 6 (4), 401-412
- https://doi.org/10.1080/01688638408401231
Abstract
The relationship of duration of illness and severity of neurological impairment to psychometric performance and activities of daily living was examined in 57 patients with Huntington's Disease (HD). As earlier studies suggested, a distinct cognitive profile characterized patients early in the disease. Duration of symptoms, however, proved to be a weaker correlate of cognitive decline than was motor impairment at the time of testing. For predicting adaptive functioning, both duration of symptoms and neurological status were important variables. This study underscores the limitations of length of illness as a classificatory variable in studies of dementia in HD. We further suggest that future studies consider the contribution of defects in precise timing and sequential operations to the cognitive and adaptive deficits of these patients.Keywords
This publication has 16 references indexed in Scilit:
- The association of affective disorder with Huntington's Disease in a case series and in familiesPsychological Medicine, 1983
- Patterns of intellectual deficit in Huntington's diseaseJournal of Clinical Neuropsychology, 1982
- Neuropsychological Deficits in Early, Middle, and Late Stage Huntington's Disease as Measured by the Luria-Nebraska Neuropsychological BatteryInternational Journal of Neuroscience, 1981
- Comparison of the Neuropsychological Deficits Associated With Early and Advanced Huntington's DiseaseArchives of Neurology, 1978
- Huntington's DementiaArchives of General Psychiatry, 1978
- An outline for the analysis of dementiaNeurology, 1977
- PATTERNS OF NEUROPSYCHOLOGICAL TEST PERFORMANCE IN HUNTINGTONʼS DISEASEThe Journal of Nervous and Mental Disease, 1975
- Pattern of intellectual impairment in Huntington's choreaPsychological Medicine, 1975
- The `subcortical dementia' of progressive supranuclear palsyJournal of Neurology, Neurosurgery & Psychiatry, 1974
- NEUROPSYCHOLOGICAL AND EMOTIONAL CORRELATES OF HUNTINGTON??S CHOREAThe Journal of Nervous and Mental Disease, 1974