Nkx2-1: a novel tumor biomarker of lung cancer
- 8 November 2012
- journal article
- review article
- Published by Zhejiang University Press in Journal of Zhejiang University-SCIENCE B
- Vol. 13 (11), 855-866
- https://doi.org/10.1631/jzus.b1100382
Abstract
Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.Keywords
This publication has 97 references indexed in Scilit:
- Suppression of lung adenocarcinoma progression by Nkx2-1Nature, 2011
- Both Gene Amplification and Allelic Loss Occur at 14q13.3 in Lung CancerClinical Cancer Research, 2011
- Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995–2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry dataThe Lancet, 2011
- Immunohistochemical Panel to Identify the Primary Site of Invasive Micropapillary CarcinomaThe American Journal of Surgical Pathology, 2009
- Characterizing the developmental pathways TTF-1 , NKX2–8 , and PAX9 in lung cancerProceedings of the National Academy of Sciences of the United States of America, 2009
- Clinical significance of TTF‐1 protein expression and TTF‐1 gene amplification in lung adenocarcinomaJournal of Cellular and Molecular Medicine, 2008
- Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancerOncogene, 2008
- Characterizing the cancer genome in lung adenocarcinomaNature, 2007
- Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancerProceedings of the National Academy of Sciences of the United States of America, 2007
- Permissive Effects of Oxygen on Cyclic AMP and Interleukin-1 Stimulation of Surfactant Protein A Gene Expression Are Mediated by Epigenetic MechanismsMolecular and Cellular Biology, 2006