Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors
- 12 June 2007
- journal article
- clinical trial
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 104 (24), 10152-10157
- https://doi.org/10.1073/pnas.0702916104
Abstract
We have recently shown that low intensity, intermediate frequency, electric fields inhibit by an anti-microtubule mechanism of action, cancerous cell growth in vitro. Using implanted electrodes, these fields were also shown to inhibit the growth of dermal tumors in mice. The present study extends these findings to additional cell lines [human breast carcinoma; MDA-MB-231, and human non-small-cell lung carcinoma (H1299)] and to animal tumor models (intradermal B16F1 melanoma and intracranial F-98 glioma) using external insulated electrodes. These findings led to the initiation of a pilot clinical trial of the effects of TTFields in 10 patients with recurrent glioblastoma (GBM). Median time to disease progression in these patients was 26.1 weeks and median overall survival was 62.2 weeks. These time to disease progression and OS values are more than double the reported medians of historical control patients. No device-related serious adverse events were seen after >70 months of cumulative treatment in all of the patients. The only device-related side effect seen was a mild to moderate contact dermatitis beneath the field delivering electrodes. We conclude that TTFields are a safe and effective new treatment modality which effectively slows down tumor growth in vitro, in vivo and, as demonstrated here, in human cancer patients.Keywords
This publication has 27 references indexed in Scilit:
- Temozolomide in the treatment of recurrent malignant gliomaCancer, 2004
- Phase II Trial of Gefitinib in Recurrent GlioblastomaJournal of Clinical Oncology, 2004
- Dielectrophoretic manipulation of macromolecules: The electric fieldPhysical Review E, 2001
- A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapseBritish Journal of Cancer, 2000
- Electrorotation of colloidal particles and cells depends on surface chargeBiophysical Journal, 1997
- Ca2+-dependent mechanisms of cytotoxicity and programmed cell deathToxicology Letters, 1992
- Characterization of the Pore Transport Properties and Tissue Alteration of Excised Human Skin during IontophoresisJournal of Pharmaceutical Sciences, 1988
- Characterization of electric field-induced fusion in erythrocyte ghost membranes.The Journal of cell biology, 1984
- The Distribution of Radiofrequency Current and BurnsAnesthesiology, 1973
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958