Role of Mitogen Activated Protein Kinase Signaling in Parkinson’s Disease
Open Access
- 29 September 2018
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 19 (10), 2973
- https://doi.org/10.3390/ijms19102973
Abstract
Parkinson’s disease (PD) is a neurodegenerative disorder caused by insufficient dopamine production due to the loss of 50% to 70% of dopaminergic neurons. A shortage of dopamine, which is predominantly produced by the dopaminergic neurons within the substantia nigra, causes clinical symptoms such as reduction of muscle mass, impaired body balance, akinesia, bradykinesia, tremors, postural instability, etc. Lastly, this can lead to a total loss of physical movement and death. Since no cure for PD has been developed up to now, researchers using cell cultures and animal models focus their work on searching for potential therapeutic targets in order to develop effective treatments. In recent years, genetic studies have prominently advocated for the role of improper protein phosphorylation caused by a dysfunction in kinases and/or phosphatases as an important player in progression and pathogenesis of PD. Thus, in this review, we focus on the role of selected MAP kinases such as JNKs, ERK1/2, and p38 MAP kinases in PD pathology.Funding Information
- Narodowe Centrum Nauki (2014/15/B/NZ4/05041)
This publication has 120 references indexed in Scilit:
- JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia CellsMediators of Inflammation, 2013
- Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK PathwayPLOS ONE, 2013
- Immunogenicity of Two FMDV Nonameric Peptides Encapsulated in Liposomes in Mice and the Protective Efficacy in Guinea PigsPLOS ONE, 2013
- Levodopa Activates Apoptosis Signaling Kinase 1 (ASK1) and Promotes Apoptosis in a Neuronal Model: Implications for the Treatment of Parkinson's DiseaseChemical Research in Toxicology, 2011
- Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein KinasesMicrobiology and Molecular Biology Reviews, 2011
- JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-Hydroxydopamine Model of Parkinson’s DiseaseACS Chemical Neuroscience, 2011
- Kinesin-1 Regulates Microtubule Dynamics via a c-Jun N-terminal Kinase-dependent MechanismOnline Journal of Public Health Informatics, 2009
- Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascadesEuropean Journal of Neuroscience, 2009
- Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNKThe EMBO Journal, 2008
- Activation and signaling of the p38 MAP kinase pathwayCell Research, 2005