How to investigate oxygen supply, uptake, and utilization simultaneously by interleaved NMR imaging and spectroscopy of the skeletal muscle
- 9 September 2005
- journal article
- clinical trial
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 54 (4), 1010-1013
- https://doi.org/10.1002/mrm.20649
Abstract
Human skeletal muscle perfusion, oxygenation, and high‐energy phosphate distribution were measured simultaneously by interleaved 1H and 31P NMR spectroscopy and 1H NMR imaging in vivo. From these parameters, arterial oxygen supply (DO2), muscle reoxygenation rate, mitochondrial ATP production, and O2 consumption (VO2) were deduced at the recovery phase of a short ischemic exercise bout. In addition, by using a reformulation of the mass conservation law, muscle maximum O2 extraction was calculated from these parameters. Magn Reson Med, 2005.Keywords
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