Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis

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Abstract
Osteoarthritis is the most common form of arthritis and a leading cause of disability among adults.1 A report from 2012 estimated that knee osteoarthritis affected more than 250 million people worldwide.2 Clinical guidelines recommend strength training for patients with knee osteoarthritis based on clinical trial evidence of effectiveness.3 Improved strength mediates pain relief,4 enhances psychological well-being,5 maintains cartilage integrity in animal models,6,7 and may increase the shock absorbing capability of lower extremity muscles during walking.8 Limitations of prior randomized trials of strength training for patients with osteoarthritis include the use of training intensities below those recommended by practice guidelines9-13 and use of short-duration interventions, lasting between 6 and 24 weeks.11,12