Olfactory function in young adolescents with Down's syndrome.
Open Access
- 1 October 1996
- journal article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 61 (4), 412-414
- https://doi.org/10.1136/jnnp.61.4.412
Abstract
Decreased ability to smell is present in adults with Down's syndrome, many of whom are known to have brain pathology analogous to that seen in Alzheimer's disease. Because olfactory loss is well documented in Alzheimer's disease, the question arises whether young adolescents with Down's syndrome, who have no clear Alzheimer's disease-like neuropathology, also exhibit olfactory dysfunction. To consider this issue, standardised tests of odour discrimination and identification were administered to 20 young adolescents with Down's syndrome (mean age (SD) 13.89 (1.98) years) and their test scores were compared with 20 mentally retarded and 20 non-mentally retarded control subjects matched to the patients with Down's syndrome on the basis of cognitive ability. No significant differences in olfactory function were found among the three study groups. These findings, along with those from studies of olfactory function in older patients with Down's syndrome, suggest that Down's syndrome related olfactory dysfunction occurs only at ages when Alzheimer's disease-like pathology is present.Keywords
This publication has 20 references indexed in Scilit:
- Olfactory identification deficits in down's syndrome and idiopathic mental retardationNeuropsychologia, 1993
- Smell and taste function in the visually impairedPerception & Psychophysics, 1993
- Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1992
- Internal consistency reliability of the fractionated and whole University of Pennsylvania Smell Identification TestPerception & Psychophysics, 1989
- Alzheimer's disease and Down's syndromeHistopathology, 1988
- Down's Syndrome and Alzheimer's disease: a reviewPsychological Medicine, 1986
- Will the study of down syndrome solve the riddle of alzheimer disease?The Journal of Pediatrics, 1986
- Internal consistency and short-term test-retest reliability of the University of Pennsylvania Smell Identification TestChemical Senses, 1985
- Development of the university of pennsylvania smell identification test: A standardized microencapsulated test of olfactory functionPhysiology & Behavior, 1984
- Alzheimer's Disease and Down's Syndrome*Annals of the New York Academy of Sciences, 1982