The Genome of Simian Virus 40
- 5 May 1978
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4341), 494-502
- https://doi.org/10.1126/science.205947
Abstract
The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5' end of late messenger RNA. The sequence of the early region is consistent with recent proposals that the large early polypeptide of SV40 is encoded in noncontinguous segments of DNA.Keywords
This publication has 62 references indexed in Scilit:
- Physical Structure of the Replication Origin of Bacteriophage LambdaScience, 1977
- Initiation points for DNA replication in nontransformed and simian virus 40-transformed Chinese hamster lung cellsCell, 1977
- The early region of SV40 DNA may have more than one geneCell, 1977
- Nucleotide sequence around the replication origin of polyoma virus DNAFEBS Letters, 1977
- Occurrence of reiterated sequences in an untranslated region of simian virus 40 DNA determined by nucleotide sequence analysisCell, 1977
- Nucleotide sequence of simian virus 40 Hind H restriction fragmentJournal of Molecular Biology, 1977
- Synthesis of the tumour antigen and the major capsid protein of simian virus 40 in a cell-free system derived from Escherichia coliJournal of Molecular Biology, 1976
- Nucleotide sequence with elements of an unusual two-fold rotational symmetry in the region of origin of replication of SV40 DNABiochemical and Biophysical Research Communications, 1976
- Studies of Simian virus 40 DNA: VII. A cleavage map of the SV40 genomeJournal of Molecular Biology, 1973
- Amino acid compositions of simian virus 40 structural proteinsBiochemical and Biophysical Research Communications, 1973