Effect of Dietary Selenite on Hepatic Organic Solvent-Soluble Lipofuscin Pigments
- 1 January 1986
- journal article
- research article
- Published by SAGE Publications in Journal of the American College of Toxicology
- Vol. 5 (1), 79-85
- https://doi.org/10.3109/10915818609140738
Abstract
Supplementation of selenium as sodium selenite results in an increase in hepatic organic solvent-soluble lipofuscin pigments, the metabolic end products of lipid peroxidation. Weanling mice fed a basal diet containing 0.05 ppm selenium had a significant increase in hepatic organic solvent-soluble lipofuscin pigments and glutathione peroxidase activity following supplementation of an additional 0.1 ppm selenium as sodium selenite from 5 to 9 months of age. Normal levels of vitamin E (30 mg/kg) were insufficient to protect against the oxidative effect of this increased dose of selenite. However, 10 times the normal level of vitamin E markedly suppressed this oxidative effect.Keywords
This publication has 15 references indexed in Scilit:
- Effect of Selenite, Vitamin E and N,N′-Diphenyl-p-Phenylenediamine on Liver Organic Solvent-Soluble Lipofuscin Pigments in MiceJournal of Nutrition, 1984
- Stimulation of Lipid Peroxidation in Vivo by Injected Selenite and Lack of Stimulation by SelenateExperimental Biology and Medicine, 1982
- Quantitative determination of organic solvent soluble lipofuscin pigments in tissuesLipids, 1976
- Glutathione peroxidase: A selenoenzymeFEBS Letters, 1973
- Selenium: Biochemical Role as a Component of Glutathione PeroxidaseScience, 1973
- Fluorescent products of lipid peroxidation of mitochondria and microsomesLipids, 1971
- Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent PigmentsScience, 1969
- Reduction of linolenic acid hydroperoxide by a glutathione peroxidaseBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
- An intracellular GSH-peroxidase with a lipid peroxide substrateBiochemical and Biophysical Research Communications, 1968
- Action of N,N'-diphenyl-p-phenylenediamine in Tocopherol Deficiency Diseases.Experimental Biology and Medicine, 1958