Transbronchial Needle Aspirates
- 1 June 2005
- journal article
- research article
- Published by Elsevier BV in Chest
- Vol. 127 (6), 2015-2018
- https://doi.org/10.1378/chest.127.6.2015
Abstract
Study objectives: Transbronchial needle aspiration has evolved as a key bronchoscopic sampling method. Specimen handling and preparation are underrated yet crucial aspects of the technique. This study was designed to identify which of two widely practiced sample preparation methods has a higher yield. Design: Prospective comparison of two diagnostic methods. Setting: Tertiary academic hospital. Patients: Consecutive patients undergoing transbronchial needle aspiration. Interventions: Transbronchial aspirates were obtained pairwise. One specimen was placed directly onto a slide and smears were prepared on site (ie, the direct technique), and the other specimen was deposited into a vial containing 95% alcohol and further prepared in the laboratory (ie, the fluid technique). In total, 282 pairs of samples were aspirated from 145 target sites (paratracheal, 10 sites; tracheobronchial, 101 sites; hilar, 17 sites; endobronchial or peripheral, 17 sites). Measurements and results: The measured outcome was the presence of diagnostic material at the final laboratory assessment. At least one diagnostic aspirate was obtained in 66% of 86 investigated patients (small cell lung cancer, 18 patients; non-small cell lung cancer, 47 patients; other diagnoses, 21 patients). The direct technique had a better yield overall than the fluid technique (positive aspirates, 36.2% vs 12.4%, respectively; p < 0.01), as well as after stratification for tumor type and for anatomic site. Conclusion: The direct technique is superior to the fluid technique for the preparation of transbronchial needle aspirates.Keywords
This publication has 7 references indexed in Scilit:
- Utility of Rapid On-Site Evaluation of Transbronchial Needle AspiratesRespiration, 2005
- Education and Experience Improve the Performance of Transbronchial Needle AspirationChest, 2004
- Bronchoscopy and needle biopsy techniques for diagnosis and staging of lung cancerClinics in Chest Medicine, 2002
- Utility of Transbronchial Needle Aspiration in the Diagnosis of Endobronchial LesionsChest, 1999
- TRANSBRONCHIAL NEEDLE ASPIRATION: An Underused Diagnostic TechniqueClinics in Chest Medicine, 1999
- Transbronchial Needle Aspiration for Histology SpecimensChest, 1989
- Flexible Transbronchial Needle Aspiration for Staging of Bronchogenic CarcinomaChest, 1983