Several lignans have been isolated from the CHCl3 extract of the wood of Abies pinsapo. These include the new compounds 4,4',9-trihydroxy-3,3'-dimethoxy-9,9'-epoxylignan [2], (9'R)-9'-hydroxylariciresinol [5], and (7'R)-7'-hydroxylariciresinol [7], as well as a novel sesquilignan with the structure (8R,8'R,8"R,9R)-4',4",9,9"-tetrahydroxy-3,3',3"-trimethoxy-4,8":.9, 9'-bis-epoxy-8,8'-sesquineolignan [8], to which we have assigned the trivial name sesquipinsapol C. Compound 2 has been identified as a mixture of epimers, while compounds 5, 7, and 8 were obtained their acetoxyl derivatives. The new structures were established by spectroscopic methods and chemical transformations. Certain antimicrobial and cytotoxic activity assays have been carried out and applied to the isolates from A. pinsapo.