Immunomodulatory Activity of Achyranthes aspera on the Elicitation of Antigen-Specific Murine Antibody Response
- 1 January 2002
- journal article
- Published by Informa UK Limited in Pharmaceutical Biology
- Vol. 40 (3), 175-178
- https://doi.org/10.1076/phbi.40.3.175.5831
Abstract
The extract of Achyranthes aspera Linn. (Amaranthaceae) was found to enhance the induction of ovalbumin (OVA)- specific humoral antibody response in mice, on intraperitoneal injection of extract along with OVA. The antibody response was evaluated by passive cutaneous anaphylaxis (PCA) and ELISA for IgE and other classes or subclasses of antibodies, respectively. Furthermore, the plant extract was found to increase the induction of OVA-specific antibody response in a dose-dependent manner. A significant elevation of IgM, IgG 1 and IgG 3 antibodies was observed (p < 0.01); however, interestingly, the anti-OVA PCA titers were suppressed. The adjuvant property of the extract was further examined in different strains of mice and a significant elevation of the OVA-specific IgG antibody response in all strains tested was found. When the extracts of different parts of the herb were tested, the seed and root extracts appeared to exhibit relatively higher activity. These results confirm the immunostimulatory properties of Achyranthes aspera.Keywords
This publication has 9 references indexed in Scilit:
- Suppressive Effect Of Withania Somnifera Root Extract on the Induction of Anti-Ovalbumin IgE Antibody Response in MicePharmaceutical Biology, 1999
- Isolation and Immunomodulating Effect of Flavonol Glycosides fromEpimedium hunanensePlanta Medica, 1997
- Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particularInternational Journal of Immunopharmacology, 1997
- Immunosuppressive Effect of Honey on the Induction of Allergen-Specific Humoral Antibody Response in MiceInternational Archives of Allergy and Immunology, 1997
- Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studiesJournal of Ethnopharmacology, 1996
- Pimelautide or Trimexautide as Built-in Adjuvants Associated with an HIV-1-Derived Peptide: Synthesis and in Vivo Induction of Antibody and Virus-Specific Cytotoxic T-Lymphocyte-Mediated ResponseJournal of Medicinal Chemistry, 1995
- Monophosphoryl Lipid A as an AdjuvantPublished by Springer Science and Business Media LLC ,1995
- Immunostimulant activity of Nyctanthes arbor-tristis L.Journal of Ethnopharmacology, 1994
- Immunostimulant Agents from Andrographis paniculataJournal of Natural Products, 1993