Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition
- 15 June 2009
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 19 (12), 3229-3232
- https://doi.org/10.1016/j.bmcl.2009.04.100
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- New Chimeric Antimalarials with 4-Aminoquinoline Moiety Linked to a Tetraoxane SkeletonJournal of Medicinal Chemistry, 2008
- A novel artemisinin–quinine hybrid with potent antimalarial activityBioorganic & Medicinal Chemistry Letters, 2007
- Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparumMolecular and Biochemical Parasitology, 2004
- Selection of Cysteine Protease Inhibitor-resistant Malaria Parasites Is Accompanied by Amplification of Falcipain Genes and Alteration in Inhibitor TransportPublished by Elsevier BV ,2004
- Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl SulfonesAntimicrobial Agents and Chemotherapy, 2003
- Cysteine proteases of parasitic organisms☆Molecular and Biochemical Parasitology, 2002
- Combination Therapy for MalariaDrugs, 2002
- Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3Biochemical Journal, 2001
- Characterization of Native and Recombinant Falcipain-2, a Principal Trophozoite Cysteine Protease and Essential Hemoglobinase ofPlasmodium falciparumPublished by Elsevier BV ,2000
- Vinyl Sulfones as Mechanism-Based Cysteine Protease InhibitorsJournal of Medicinal Chemistry, 1995