Brominated Chamigrane Sesquiterpenes Produce a Novel Profile of Differential Cytotoxicity in the NCIin vitroScreen
- 1 June 1995
- journal article
- research article
- Published by Taylor & Francis Ltd in Natural Product Letters
- Vol. 6 (4), 255-259
- https://doi.org/10.1080/10575639508043168
Abstract
Bioassay-guided fractionation of an extract from the marine alga Laurencia majuscula provided three brominated chamigrane sesquiterpenes (1–3). These compounds produced a novel pattern of antitumor activity against the National Cancer Institute's in vitro cell line panel. They were cytotoxic to certain cell lines in the colon cancer subpanel at concentrations 10–100 fold lower than the mean cytotoxic concentration observed in the other tumor subpanels.Keywords
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