Increased Risk of Hypertension After Gestational Diabetes Mellitus
Open Access
- 17 June 2011
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 34 (7), 1582-1584
- https://doi.org/10.2337/dc11-0268
Abstract
OBJECTIVE: Whether a history of gestational diabetes mellitus (GDM) is associated with an increased risk of hypertension after the index pregnancy is not well established. RESEARCH DESIGN AND METHODS: We investigated the association between GDM and subsequent risk of hypertension after the index pregnancy among 25,305 women who reported at least one singleton pregnancy between 1991 and 2007 in the Nurses’ Health Study II. RESULTS: During 16 years of follow-up, GDM developed in 1,414 women (5.6%) and hypertension developed in 3,138. A multivariable Cox proportional hazards model showed women with a history of GDM had a 26% increased risk of developing hypertension compared with those without a history of GDM (hazard ratio 1.26 [95% CI 1.11–1.43]; P = 0.0004). These results were independent of pregnancy hypertension or subsequent type 2 diabetes. CONCLUSIONS: These results indicate that women with GDM are at a significant increased risk of developing hypertension after the index pregnancy.Keywords
This publication has 12 references indexed in Scilit:
- Glucose Intolerance in Pregnancy and Postpartum Risk of Metabolic Syndrome in Young WomenJournal of Clinical Endocrinology & Metabolism, 2010
- Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysisThe Lancet, 2009
- Obesity, gestational diabetes and pregnancy outcomeSeminars in Fetal and Neonatal Medicine, 2009
- Increased Risk of Cardiovascular Disease in Young Women Following Gestational Diabetes MellitusDiabetes Care, 2008
- Summary and Recommendations of the Fifth International Workshop-Conference on Gestational Diabetes MellitusDiabetes Care, 2007
- Pregnancy as the prodrome to vascular dysfunction and cardiovascular riskNature Clinical Practice Cardiovascular Medicine, 2006
- Pancreatic B-Cell Defects in Gestational Diabetes: Implications for the Pathogenesis and Prevention of Type 2 DiabetesJournal of Clinical Endocrinology & Metabolism, 2001
- Pancreatic B-Cell Defects in Gestational Diabetes: Implications for the Pathogenesis and Prevention of Type 2 DiabetesJournal of Clinical Endocrinology & Metabolism, 2001
- Lipid Levels in Former Gestational Diabetic MothersDiabetes Care, 1996
- Lipoprotein Metabolism in Pregnancy, Fat Transport to the Fetus, and the Effects of DiabetesNeonatology, 1986