Chronic Use of β-Blockers and the Risk of Parkinson’s Disease
- 13 March 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Clinical Drug Investigation
- Vol. 39 (5), 463-468
- https://doi.org/10.1007/s40261-019-00771-y
Abstract
Most patients with Parkinson’s disease exhibit intracellular accumulation of the α-synuclein protein encoded by the α-synuclein gene. It was recently shown that β2-adrenoreceptor agonists downregulate this gene, decreasing the apparent risk of Parkinson’s disease by up to 40%. In contrast, exposure to β-blocking drugs increases production of the α-synuclein protein.This publication has 10 references indexed in Scilit:
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