Current and Future Clinical Strategies in Colon Cancer Prevention and the Emerging Role of Chemoprevention
- 1 August 2007
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Pharmaceutical Design
- Vol. 13 (22), 2274-2282
- https://doi.org/10.2174/138161207781368783
Abstract
In the third millennium preventive medicine is becoming a corner stone in our concept of health. Colorectal cancer (CRC) fits the criteria of a disease suitable for prevention interventions. It is a prevalent disease that is associated with considerable mortality and morbidity rates, with more than 1,000,000 new cases and 500,000 deaths annually. CRC has a natural history of transition from precursor to malignant lesion that spans, on average, 10-15 years, providing a window of opportunity for effective interventions and prevention. Indeed, CRC is preventable in up to 90% of the cases. Simple life style modifications (balanced diet avoidance of smoking and alcohol, and moderate physical activity) can prevent up to 50% of the cases of colorectal cancer. compliance with current screening methods is a major barrier to the achievement of optimal results, a large part of the average risk population has not been screened by any method. Several newly developed screening modalities, such as the virtual colonoscopy and stool genetic testing may improve compliance. In addition, chemoprevention, a new science that has emerged during the last decade, presents an alternative approach to reducing mortality from colorectal cancer as well as other cancers. Chemoprevention involves the long-term use of a variety of oral agents that can delay, prevent or even reverse the development of adenomas in the large bowel. In light of the recent evidence of the efficacy of chemoprevention in persons at high risk for CRC cancer, it seems only appropriate to consider similar strategies for the general population.Keywords
This publication has 18 references indexed in Scilit:
- Colonoscopy in Colorectal-Cancer Screening for Detection of Advanced NeoplasiaNew England Journal of Medicine, 2006
- Fruit and Vegetable Consumption and Colorectal Adenomas in the Nurses' Health StudyCancer Research, 2006
- Selenium supplementation and colorectal adenomas: An analysis of the nutritional prevention of cancer trialInternational Journal of Cancer, 2005
- Celecoxib and Curcumin Synergistically Inhibit the Growth of Colorectal Cancer CellsClinical Cancer Research, 2005
- Relationship Between Selective Cyclooxygenase-2 Inhibitors and Acute Myocardial Infarction in Older AdultsCirculation, 2004
- Multivitamin Use and Colorectal Cancer Incidence in a US Cohort: Does Timing Matter?American Journal of Epidemiology, 2003
- Ursodiol: Good drug makes goodGastroenterology, 2003
- Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidenceGastroenterology, 2003
- Flexible sigmoidoscopy: The patients' perceptionGastrointestinal Endoscopy, 2002
- Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal CancerNew England Journal of Medicine, 2000