New bioactive compounds fromAloe hijazensis
- 20 July 2009
- journal article
- research article
- Published by Taylor & Francis Ltd in Natural Product Research
- Vol. 23 (11), 1035-1049
- https://doi.org/10.1080/14786410802242851
Abstract
The chemical constituents and biological activities of leaves and roots of Aloe hijazensis, collected in Saudi Arabia, are reported here for the first time. Twenty-two compounds were obtained, among them eight hydroxyquinones: aloe-emodin (1), emodin (2), chrysophanol (3), aloesaponarin II 3-methyl ether (4), ziganein (5), ziganein-5-methyl ether (6a), aloesaponarin I (7) and chrysophanein (8), the dihydro-isocoumarin feralolide (9), 4,7-dichloro-quinoline (10), the triterpene lupeol (11), the anthrone aloin (12), three aloenin derivatives, aloenin (13) ethylidene-aloenin (14), and aloenin B (15), four flavonoids, quercetin (16), kaempferol (17) cosmosiin (18) and isovitexin (19), and cinnamic acid (20) and two further analogues, caffeic acid (21) and ferulic acid (22). While 15 of the isolated compounds were found in the leaves, 12 were isolated from roots of the plant. Compounds 6a and 10 are reported as new natural constituents, while the compounds 4, 5, 8, and 18 are reported here for the first time from Aloe spp. The structures of the compounds were deduced by intensive studies of their UV, NMR, MS data and by comparison with related structures. The biological activity of plant extracts was studied against various microbial strains, and potent anti-bacterial and anti-fungal activities were found.Keywords
This publication has 23 references indexed in Scilit:
- Phenolic Constituents in Dried Flowers of Aloe vera (Aloe barbadensis) and their in vitro Antioxidative CapacityPlanta Medica, 2007
- Anthrone and Oxanthrone C-Glycosides from Picramnia latifolia Collected in PeruJournal of Natural Products, 2004
- Elucidation of the substitution pattern of 9,10-anthraquinones through the chemical shifts of peri-hydroxyl protonsPhytochemistry, 1996
- Phytochemical study onAloe veraArchives of Pharmacal Research, 1996
- Feralolide, a dihydroisocoumarin from cape aloePhytochemistry, 1993
- Cytotoxic anthraquinones from Rheum pulmatumPhytochemistry, 1992
- Aloenin B, a New Diglucosylated 6-Phenyl-2-pyrone from Kenya AloeJournal of Natural Products, 1986
- Chemistry of the Coccoidea. VIII. Synthesis of the ancient dyestuff kermesic acid and of related anthraquinonesAustralian Journal of Chemistry, 1981
- In Vitro Study of A Group of Blocked Steroids as Anti-Mycotic AgentsJournal of Investigative Dermatology, 1953
- The diffusion of antiseptics through agar gels, with special reference to the agar cup assay method of estimating the activity of penicillinThe Journal of Pathology and Bacteriology, 1946