Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: a feasibility trial
Open Access
- 1 January 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Arthritis Research & Therapy
- Vol. 12 (1), R25-15
- https://doi.org/10.1186/ar2932
Abstract
Management of osteoarthritis (OA) includes the use of non-pharmacological and pharmacological therapies. Although walking is commonly recommended for reducing pain and increasing physical function in people with OA, glucosamine sulphate has also been used to alleviate pain and slow the progression of OA. This study evaluated the effects of a progressive walking program and glucosamine sulphate intake on OA symptoms and physical activity participation in people with mild to moderate hip or knee OA. Thirty-six low active participants (aged 42 to 73 years) were provided with 1500 mg glucosamine sulphate per day for 6 weeks, after which they began a 12-week progressive walking program, while continuing to take glucosamine. They were randomized to walk 3 or 5 days per week and given a pedometer to monitor step counts. For both groups, step level of walking was gradually increased to 3000 steps/day during the first 6 weeks of walking, and to 6000 steps/day for the next 6 weeks. Primary outcomes included physical activity levels, physical function (self-paced step test), and the WOMAC Osteoarthritis Index for pain, stiffness and physical function. Assessments were conducted at baseline and at 6-, 12-, 18-, and 24-week follow-ups. The Mann Whitney Test was used to examine differences in outcome measures between groups at each assessment, and the Wilcoxon Signed Ranks Test was used to examine differences in outcome measures between assessments. During the first 6 weeks of the study (glucosamine supplementation only), physical activity levels, physical function, and total WOMAC scores improved (P < 0.05). Between the start of the walking program (Week 6) and the final follow-up (Week 24), further improvements were seen in these outcomes (P < 0.05) although most improvements were seen between Weeks 6 and 12. No significant differences were found between walking groups. In people with hip or knee OA, walking a minimum of 3000 steps (~30 minutes), at least 3 days/week, in combination with glucosamine sulphate, may reduce OA symptoms. A more robust study with a larger sample is needed to support these preliminary findings. Australian Clinical Trials Registry ACTRN012607000159459.This publication has 47 references indexed in Scilit:
- Reliability and validity of a modified self‐administered version of the Active Australia physical activity survey in a sample of mid‐age womenAustralian and New Zealand Journal of Public Health, 2008
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part IIArthritis & Rheumatism, 2007
- Glucosamine therapy for treating osteoarthritisEmergencias, 2005
- Test-retest reliability of four physical activity measures used in population surveysJournal of Science and Medicine in Sport, 2004
- Antibiotic prophylaxis for patients undergoing transurethral resection of prostate who have preoperative containing <100,000 bacteria/mLPublished by Wiley ,2002
- Self-Efficacy and Pain in Disability with Osteoarthritis of the KneeThe Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 1996
- A Walking Education Program for Patients with Osteoarthritis of the Knee: Theory and Intervention StrategiesHealth Education Quarterly, 1993
- The Integration of Theory with Practice: A 12-Year Case StudyHealth Education Quarterly, 1992
- Self-Efficacy and the Stages of Exercise Behavior ChangeResearch Quarterly for Exercise and Sport, 1992
- Development and evaluation of a scale to measure perceived self‐efficacy in people with arthritisArthritis & Rheumatism, 1989