N-Phenyl-N-purin-6-yl ureas: The design and synthesis of p38α MAP kinase inhibitors
- 24 March 2003
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 13 (6), 1191-1194
- https://doi.org/10.1016/s0960-894x(03)00048-9
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Inhibition of p38 MAP kinase by utilizing a novel allosteric binding siteNature Structural & Molecular Biology, 2002
- TUMOR NECROSIS FACTOR-α BLOCKADE IN THE TREATMENT OF RHEUMATOID ARTHRITISRheumatic Disease Clinics of North America, 2001
- Anti‐TNF agents for rheumatoid arthritisBritish Journal of Clinical Pharmacology, 2001
- 1 p38 MAP Kinase: Molecular Target for the Inhibition of Pro-inflammatory CytokinesProgress in Medicinal Chemistry, 2001
- New inhibitors of p38 kinaseExpert Opinion on Therapeutic Patents, 2000
- p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic PotentialsPharmacology & Therapeutics, 1999
- Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymesBioorganic & Medicinal Chemistry Letters, 1998
- Structural basis of inhibitor selectivity in MAP kinasesStructure, 1998
- A Structure-Based Library Approach to Kinase InhibitorsJournal of the American Chemical Society, 1996
- A protein kinase involved in the regulation of inflammatory cytokine biosynthesisNature, 1994