A multimarker approach to assess the influence of inflammation on the incidence of atrial fibrillation in women
Open Access
- 25 May 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 31 (14), 1730-1736
- https://doi.org/10.1093/eurheartj/ehq146
Abstract
To assess the joint influence of inflammatory biomarkers on the risk of incident atrial fibrillation (AF) in women. We performed a prospective cohort study among women participating in the Women's Health Study. All women were free of AF at study entry and provided a baseline blood sample assayed for high-sensitivity C-reactive protein, soluble intercellular adhesion molecule-1, and fibrinogen. To evaluate the joint effect of these three biomarkers, an inflammation score was created that ranged from 0 to 3 and reflected the number of biomarkers in the highest tertile per individual. During a median follow-up of 14.4 years, 747 of 24 734 women (3.0%) experienced a first AF event. Assessed individually, all three biomarkers were associated with incident AF, even after adjustment for traditional risk factors. When combined into an inflammation score, a strong and independent relationship between inflammation and incident AF emerged. Across increasing inflammation score categories, there were 1.66, 2.22, 2.73, and 3.25 AF events per 1000 person-years of follow-up. The corresponding hazard ratios (95% confidence intervals) across inflammation score categories were 1.0, 1.22 (1.00–1.49), 1.32 (1.06–1.65), and 1.59 (1.22–2.06) (P for linear trend 0.0006) after multivariable adjustment. In this large-scale prospective study among women without a history of cardiovascular disease, markers of systemic inflammation were significantly related to AF even after controlling for traditional risk factors.Keywords
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