The slowing of gastric emptying by four strong acids and three weak acids
- 1 April 1972
- journal article
- Published by Wiley in The Journal of Physiology
- Vol. 222 (1), 187-208
- https://doi.org/10.1113/jphysiol.1972.sp009793
Abstract
1. Test meals of 750 ml. water containing a range of concentrations of hydrochloric, nitric, sulphuric, cyclamic (cyclohexylsulphamic), tartaric, L-ascorbic and citric acids were instilled into the stomachs of sixteen healthy subjects.2. The greater the concentration of an acid in the instilled meal, the greater was the volume of meal recovered after a fixed interval.3. For the weak acids, tartaric, ascorbic and citric, the concentrations which gave a recovery of 450 ml., out of the 750 ml. instilled, increased with increase in the molecular weight of the acid.4. For the strong acids, hydrochloric, nitric, sulphuric and cyclamic, the concentrations which gave a recovery of 450 ml., out of the 750 ml. instilled, were approximately equal. These concentrations were less than those for weak acids.5. The strong acids with high molecular weights were slightly more effective in slowing gastric emptying than were those with low molecular weights.6. The approximate equality of effectiveness of nitric, sulphuric and cyclamic acids to hydrochloric acid is attributed to the presence of chloride ion in the duodenal contents. Thus all the strong acids instilled produce an environment of hydrochloric acid around the receptor.7. A model for a duodenal receptor responding to acids is proposed.This publication has 7 references indexed in Scilit:
- Gastric Nonabsorbable Indicators for Studies in ManGastroenterology, 1970
- A relation between gastroduodenal muscle contractions and gastric empyting.Gut, 1969
- The slowing of gastric emptying by nine acidsThe Journal of Physiology, 1969
- A relation between the chain length of fatty acids and the slowing of gastric emptyingThe Journal of Physiology, 1968
- The regulation of gastric emptying of meals containing citric acid and salts of citric acidThe Journal of Physiology, 1962
- The osmotic effects of some simple molecules and ions on gastric emptyingThe Journal of Physiology, 1960
- The absorption of water and of some small solute molecules from the isolated small intestine of the ratThe Journal of Physiology, 1955