Changes in Children’s Reports of Symptom Occurrence and Severity During a Course of Myelosuppressive Chemotherapy
- 25 August 2010
- journal article
- Published by SAGE Publications in Journal of Pediatric Oncology Nursing
- Vol. 27 (6), 307-315
- https://doi.org/10.1177/1043454210377619
Abstract
The purposes of this study in children who underwent a cycle of myelosuppressive chemotherapy were to describe changes in symptom occurrence and severity during the chemotherapy cycle. Patients (N = 66) 10 to 18 years of age completed the Memorial Symptom Assessment Scale for 10- to 18-year-olds (MSAS 10-18) at the start of a chemotherapy cycle (T1) and weekly for the next 2 weeks (T2 and T3). More than 30% of children reported 10 or more symptoms at all 3 time points. Symptom occurrence trajectories were tested with multilevel logistic regression. In all, 6 symptoms (ie, fatigue, sadness, irritability, worrying, weight loss, sweating) showed a decreasing linear trend. Significant quadratic patterns of change were found for feeling drowsy, nausea, and vomiting. Changes in symptom severity over time were evaluated with multilevel negative binomial regression. No significant differences over time were found in any of the symptom severity scores on the MSAS. Children experienced a high number of symptoms at the initiation of a chemotherapy cycle that persisted over the subsequent 2 weeks.Keywords
This publication has 39 references indexed in Scilit:
- Multiple Symptoms in Pediatric Oncology Patients: A Systematic ReviewJournal of Pediatric Oncology Nursing, 2009
- Validation of modified forms of the PedsQL generic core scales and cancer module scales for adolescents and young adults (AYA) with cancer or a blood disorderQuality of Life Research, 2009
- Impact of Effective Nursing Interventions to the Fatigue Syndrome in Children Who Receive ChemotherapyCancer Nursing, 2008
- Physical problems and psychosocial function in children with cancerPaediatric Nursing, 2008
- Prevalence of aspects of distress, coping, support and care among adolescents and young adults undergoing and being off cancer treatmentEuropean Journal of Oncology Nursing, 2007
- Delayed Nausea and Vomiting Continue to Reduce Patients' Quality of Life After Highly and Moderately Emetogenic Chemotherapy Despite Antiemetic TreatmentJournal of Clinical Oncology, 2006
- Quality of life following allogeneic stem cell transplantation, comparing parents' and children's perspectivePediatric Transplantation, 2006
- Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancerInternational Journal of Radiation Oncology*Biology*Physics, 2002
- The Measurement of Symptoms in Young Children With CancerJournal of Pain and Symptom Management, 2002
- The Measurement of Symptoms in Children with CancerJournal of Pain and Symptom Management, 2000