Pharmacokinetics of metoprolol enantiomers in Chinese subjects of major genotypes

Abstract

CYP2D6 mediates both α‐hydroxylation and O‐demethylation of metoprolol. In Chinese subjects, CYP2D6*1 (the wild‐type) alleles are relatively uncommon. Subjects with P34S (C188 →T188) and S486T (G4268 →C4268) mutations (CYP2D6J or CYP2D6*10A) are more frequently seen. Recently, the CYP2D6*2 (CYP2D6L) genotype that results in R296C (C2938 →T2938) and S486T mutations was also found important. In this study, metoprolol pharmacokinetics was investigated in subjects of these 3 major genotypes.