Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers
- 1 August 2004
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 287 (2), C246-C256
- https://doi.org/10.1152/ajpcell.00516.2003
Abstract
Except for the role of NO in the activation of guanylate cyclase, which is well established, the involvement of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in signal transduction remains controversial, despite a large body of evidence suggestive of their participation in a variety of signaling pathways. Several problems have limited their acceptance as signaling molecules, with the major one being the difficulty in identifying the specific targets for each pathway and the chemical reactions supporting reversible oxidation of these signaling components, consistent with a second messenger role for ROS and RNS. Nevertheless, it has become clear that cysteine residues in the thiolate (i.e., ionized) form that are found in some proteins can be specific targets for reaction with H2O2and RNS. This review focuses on the chemistry of the reversible oxidation of those thiolates, with a particular emphasis on the critical thiolate found in protein tyrosine phosphatases as an example.Keywords
This publication has 110 references indexed in Scilit:
- ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxinNature, 2003
- Redox signaling: hydrogen peroxide as intracellular messengerExperimental & Molecular Medicine, 1999
- Monitoring Antisense Oligodeoxynucleotide Activity in Hematopoietic CellsMethods, 1999
- Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-NitrosylationBiochemical and Biophysical Research Communications, 1997
- Redox modulation of tyrosine phosphorylation-dependent signal transduction pathwaysFree Radical Biology & Medicine, 1996
- Thioredoxin-Linked Peroxidase from Human Red Blood Cell: Evidence for the Existence of Thioredoxin and Thioredoxin Reductase in Human Red Blood CellBiochemical and Biophysical Research Communications, 1995
- Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cellsFree Radical Biology & Medicine, 1994
- Transnitrosation between nitrosothiols and thiolsJournal of the Chemical Society, Perkin Transactions 2, 1994
- Redox reactivity of iron(III) porphyrins and heme proteins with nitric oxide. Nitrosyl transfer to carbon, oxygen, nitrogen and sulfurChemical Research in Toxicology, 1990
- Hydrogen peroxide elicits activation of bovine pulmonary arterial soluble guanylate cyclase by a mechanism associated with its metabolism by catalaseBiochemical and Biophysical Research Communications, 1987