Osteoclast-Derived Extracellular Vesicles: Novel Regulators of Osteoclastogenesis and Osteoclast–Osteoblasts Communication in Bone Remodeling
Open Access
- 30 May 2018
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Physiology
- Vol. 9, 628
- https://doi.org/10.3389/fphys.2018.00628
Abstract
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play an important role in cellular communication during skeletal growth and homeostasis. Bioactive molecules carried by EVs are transported to neighboring and distant cells to trigger a series of signaling cascades influencing bone homeostasis. The bioactive activities of osteoclast-derived EVs include regulation of osteoclastogenesis and osteoclast–osteoblast communication. As osteoclast-derived EVs have the potential to regulate osteoclasts and osteoblasts, their application in osteoporosis and other bone metabolic disorders is currently under investigation. However, very few reviews of osteoclast-derived EVs in bone remodeling regulation have yet been published. This article aims to review recent advances in this field, summarizing a new regulator of osteoclastogenesis and osteoclast–osteoblast communication mediated by osteoclast-derived EVs. We will analyze the major challenges in the field and potential for the therapeutic application of EVs.Keywords
Funding Information
- National Natural Science Foundation of China (81770876)
This publication has 51 references indexed in Scilit:
- Foxc2 regulates osteogenesis and angiogenesis of bone marrow mesenchymal stem cellsBMC Musculoskeletal Disorders, 2013
- Extracellular Vesicle (EV) Array: microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotypingJournal of Extracellular Vesicles, 2013
- Targeting osteoclast-osteoblast communicationNature Medicine, 2011
- Suppression of bone formation by osteoclastic expression of semaphorin 4DNature Medicine, 2011
- The role of interleukin-17 in mediating joint destruction in rheumatoid arthritisBiochemical and Biophysical Research Communications, 2010
- Receptor Activator for Nuclear Factor kappa B Ligand (RANKL) as an osteoimmune key regulator in bone physiology and pathologyActa Histochemica, 2009
- TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formationNature Medicine, 2009
- Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasisNature, 2009
- Osteoclast–osteoblast communicationArchives of Biochemistry and Biophysics, 2008
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007